Lincoln Rhyme (Denzel Washington) is a bedridden quadriplegic and ex-forensic expert. Amelia Donaghy (Angelina Jolie) is a New York patrol cop with a knack for crime solving.
A serial killer is on the loose. He poses as a taxi driver, abducts his victims and then kills them in the most horrific ways. No two killings are done in the same way.
Together, the bedridden Rhyme and the beautiful Donaghy must team together to stop this manic killer on the prowl. But this is no ordinary killer, this is a killer who kills his victims in a logical sequence, and he seems to know forensics equally as well as the police. And they need to get him before he gets them.